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Major Breakthrough in HIV Research: Study Published Today Online in The Journal of Experimental Medicine Identifies Population of Cells Serving as the Major Reservoir for HIV
LAUSANNE, Switzerland--(BUSINESS WIRE)--A study published today online in The Journal of Experimental Medicine has identified the population of CD4 T cells serving as the major reservoir for HIV infected cells and as the primary cell site for HIV replication and production in infected patients. The study was led by Prof. Giuseppe Pantaleo and Dr. Matthieu Perreau at the Division of Immunology and Allergy and at the Swiss Vaccine Research Institute, Lausanne University Hospital, Lausanne, Switzerland.
CD4 T cells are known to be the primary target of HIV. The CD4 T cells serving as reservoir for HIV infection and as primary site for HIV replication and production are not present in the blood and are exclusively found in the lymphoid tissues in a region called germinal centers. These CD4 T cells are called ‘T follicular helper’ (Tfh) cells: they represent about 2% of the total CD4 T cells residing in the lymphoid tissues and are in close contact with B cells and help B cells to mature and produce antibodies.
“This is a major discovery for the HIV field; we have finally identified the cell population predominantly responsible for supporting active HIV replication and production,” says Prof. Pantaleo. “We have also provided evidence that the Tfh cells are likely to be responsible for residual virus replication in patients effectively treated with antiretroviral therapy.”
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